Epcam biology
WebFeb 13, 2024 · Epithelial–mesenchymal transition (EMT) is an important biological process that has been implicated in cancer metastasis. Epithelial cell adhesion molecule (EpCAM) is expressed at the ... WebJul 17, 2015 · EpCAM expressing circulating tumor cells, detected by CellSearch, are predictive of short survival in several cancers and may serve as a liquid biopsy to guide therapy. Here we investigate the ...
Epcam biology
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WebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more
WebAug 1, 2013 · EpCAM is a cell surface glycoprotein of approximately 40 kDa (detailed below) that is highly expressed in epithelial cancers and at lower levels in normal simple … WebJan 6, 2024 · In this perspective, we thought of investigating epithelial cell adhesion molecule (EpCAM) as a potential molecule. EpCAM is a CSC surface marker that was …
WebFeb 15, 2015 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue progenitors, and embryonic and adult stem cells. During liver development, EpCAM demonstrates a dynamic expression, since it can be detected in fetal liver, … WebThe epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. ... Here, we provide a comprehensive review of the current knowledge on EpCAM biology in relation to ...
WebAug 28, 2014 · EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell–cell adhesion via intercellular oligomerization and ...
WebMay 31, 2024 · EpCAM (CD326) is a conserved type I transmembrane glycoprotein of 35 kDa expressed on epithelial cells of higher eukaryotes. It was initially discovered as a … ark akreditasi adalahWebMay 21, 2024 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM … balik restaurant menuWebStreptavidin-PE was used to place all the lineage marker-positive cells in the PE channel, and EpCAM-APC was used to stain all epithelial cells. At the same time, cells were stained with Annexin V and 7-amino-actinomycin D (7-AAD, PE Annexin V Apoptosis Detection Kit I, BD Biosciences) according to the manufacturer's instructions. balik restaurant near meWebMar 31, 2024 · Each discovery in RNA biology [e.g., primer in CRISPR (7, 8), ... Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the … arkakiranahWebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells … bali kreta beach barWebEpithelial Cell Adhesion Molecule. The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein which is typically expressed by cancers originating from epithelial tissue [94–97], and not expressed in hematological cells. From: Advances in Clinical Chemistry, 2024. Related terms: T Cell; Cancer Stem Cell; CD44; CD133 balik salmoneWebOct 25, 2010 · EpCAM has been long known as a tumor-associated antigen highly expressed in a variety of carcinomas (Koprowski et al., 1979).It is used as a marker for aggressive tumors, and has been considered as a potential target for immunotherapy (Osta et al., 2004).In human and mouse, EpCAM is expressed in embryonic epithelia, but the … balik rumah tong tong chiang