Itm2b
WebITM2B Antibody (C-term) (Cat. #AP13163b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITM2B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. WebWe reported that the integral membrane 2B gene (ITM2B, also called BRI2) is a target of BCL6 repression in lymphomas.Molecular alterations in ITM2B are associated with 2 neurodegenerative diseases, Familial British and Danish dementia, and dysregulation of ITM2B function has been implicated in the pathogenesis of Alzheimer disease (AD). …
Itm2b
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WebMature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed … Web23 okt. 2024 · It was indicated that the expression levels of 2 non-coding RNAs (n324674 and ENST00000442382) were significantly elevated, while a total of 4 mRNAs, regulator of G-protein signaling 18 (RGS18), integral membrane protein 2B (ITM2B), pro-platelet basic protein (PPBP) and nucleosome assembly protein1-like 1 (NAP1L1), were reduced in the …
WebDefects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) [MIM:117300]; also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Web1 apr. 2024 · Purpose: To reappraise the presentation and the course of ITM2B-related retinal dystrophy and give further insights into ITM2B expression in the retina. Methods: The clinical data of nine subjects with ITM2B-related retinal dystrophy were retrospectively reviewed. The genetic mutation was assessed for its influence on splicing in cultured …
Web1 apr. 2024 · ITM2B mRNA is expressed in all cellular types of the inner retina. Disease mechanism most likely involves mutant protein misfolding and/or modified protein … Web26 aug. 2024 · ITM2B interactome in the retina with the 254 proteins purified with the mouse antibody (FC > 2 and p-value < 0.01). ( a) GO-term network analysis. ( b) Functional …
WebOrphanet 58 Itm2b amyloidosis: A rare, neurodegenerative disease characterized by progressive dementia and ataxia, widespread cerebral amyloid angiopathy and parenchymal amyloid deposition. Two subtypes have been identified, …
Web4 apr. 2024 · Tel.: +82 63 250 1218; Fax: +82 250 1200; E-mail: [email protected] . Abstract: Mutations in ITM2B have been reported to be associated with several familial dementias, such as Familial British dementia and familial Danish dementia. These are autosomal dominant disorders characterized by progressive dementia with an onset at … cvs coxbridge farmWebITM2B. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. cvs cox and broad richmondWebwhether pathogenic ITM2b mutations affect these physiolog-ical BRI2 functions, we analyzed glutamatergic transmission in FDD and FBD knock-in mice, which carry pathogenic FDD and FBD mutations into the mouse endogenous Itm2b gene. We show that in both mutant lines, spontaneous glutamate release and AMPAR-mediated responses are … cheapest new vauxhall corsaWebAnti-ITM2B antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonyms: BRI,BRI2,BRICD2B,E25B,E3-16; find Sigma-Aldrich-HPA071992 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich cvs cox and broad street richmond vaWeb1 mei 2015 · Molecular alterations in the ITM2B gene are associated with two neurodegenerative diseases, Familial British and Familial Danish dementia. ITM2B … cheapest new trucks for sale for $2000WebMutations in ITM2B have been reported to be associated with several familial dementias, such as Familial British dementia and familial Danish dementia. These are autosomal dominant disorders characterized by progressive dementia with an onset at around the fifth decade of life. We describe a family … cvs cox and forest dallasWebDefects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) [MIM:117300]; also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. cvs cox and broad street richmond