Web24 Jun 2024 · SUMO is frequently conjugated to a lysine situated in the sumoylation consensus motif ΨKxE, where Ψ represents a large hydrophobic amino acid. SUMO … WebThe SIM domain contains the four SUMO interaction motifs (SIMs) of RING-finger 4 (RNF4). This SIM domain prefers binding polySUMO chains with four or more SUMOs. It is useful for enrichment of polysumolyated proteins or polySUMO chains. 基 …
SUMOgo: Prediction of sumoylation sites on lysines by motif
WebSUMO-modified proteins through specific SUMO interaction motifs (SIMs) in its C-ter-minal domain. Impairing the SUMO interactions mediated by Yen1’s SIMs results in a deficient function of this factor during the resolution of joint DNA molecules that would otherwise prevent the chromosomes to fully separate and segregate to the two daughter Web18 Nov 2024 · SUMO-dependent interactors of PML are involved in transcription, DNA damage, stress response and SUMO modification and are highly enriched in SUMO … clearvision hauppauge ny jobs
SUMO Interacting Motifs: Structure and Function - PubMed
Web13 Jan 2024 · Using computational modeling and experimental validations, we uncovered and confirmed two SUMO-interacting motifs (SIMs) that were the binding targets of our SUMO1-derived peptide inhibitor via SUMO-SIM interactions. Notably, the two SIMs were located within the N-terminal region flanking the α-synuclein non-amyloid-β component … WebBinding properties of SUMO-interacting motifs (SIMs) in yeast. Small ubiquitin-like modifier (SUMO) conjugation and interaction play an essential role in many cellular processes. A … Web15 Nov 2016 · RNF4 uses multiple SUMO interaction motifs (SIMs) to bind to these chains. However, in addition to polySUMO chains, a multimeric binding surface created by the simultaneous SUMOylation of multiple residues on a protein or complex could also provide a platform for the recruitment of multi-SIM proteins like RNF4. clear vision investments